ITI214 free base ( ITI-214 free base;ITI 214 free base )

Catalog No. M10556 CAS No. 1160521-50-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ITI214 free base
Note

Research use only, not for human use.
Brief Description

ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM.
Description

ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms; improves the memory processes of acquisition, consolidation, and retrieval across a broad dose range (0.1-10 mg/kg, po) without disrupting the antipsychotic-like activity of a clinical antipsychotic medication, shows potential for schizophrenia and Alzheimer's disease, movement disorders, attention deficit and hyperactivity disorders, and other central nervous system (CNS) and non-CNS disorders.Parkinson Disease Phase 2 Clinical
Synonyms

ITI-214 free base;ITI 214 free base
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Neurological Disease
Indication

Parkinson Disease

CAS Number

1160521-50-5
Formula Weight

507.56
Molecular Formula

C29H26FN7O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CN1C(=O)C2=C(N(N=C2N3C1=NC4C3CCC4)CC5=CC=C(C=C5)C6=NC(=CC=C6)F)NC7=CC=CC=C7
Chemical Name

Cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, 2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-, (6aR,9aS)-

1. Li P, et al. J Med Chem. 2016 Feb 11;59(3):1149-64.
2. Snyder GL, et al. Psychopharmacology (Berl). 2016 Sep;233(17):3113-24.

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